Digital Pathology

A world leader in image enhancement, ContextVision’s state-of-the-art products are used in over 300,000 medical imaging systems worldwide. Building on the latest advances in technology, we have constantly shifted the boundaries of ultrasound, radiography, mammography and MRI.

With INIFY® Prostate Screening we are now entering the fast-growing digital pathology market. We are re-investing significantly in our product portfolio of decision support tools and we are dedicated to becoming a leading resource for pathologists to radically develop cancer diagnosis and improve patient care.

Power to the pathologist

INIFY® Prostate Screening is an AI-powered tool that provides pathologists with valuable decision support when identifying cancer in prostate biopsies. Exploring the advantages of today’s digital technology in whole new ways, and drawing on the very latest breakthroughs in deep learning, INIFY Prostate Screening empowers pathologists faced with today’s ever-increasing workload. It makes room for smarter, more accurate and faster decisions, is proven to be robust across different labs and scanners, and is adaptable to different workflows and user needs. INIFY Prostate Screening builds on the resilient foundation of innovation, technical know-how and professionalism that has been a trademark of ContextVision for the last 30 years.
INIFY® is a registered trademark of ContextVision AB
2020-06-29
We are proud to announce that INIFY® Prostate Screening has been granted CE mark status, and is now available for routine clinical use within the European Union.
2020-12-01
In this episode, ContextVision's product manager Kristian Eurén explains the first of INIFY® Prostate Screening's superpowers: FAST. Subscribe for more insights into the superpowers of INIFY.

00:46 Pre-processed, pre-analyzed slides speed up workflow
01:15 The viewer’s time-saving features
01:43 Smart annotation tools
02:05 Pre-sorted slides
02:23 Synchronized IHC slides and HE slides
02:36 Can pathologists correct the results?
03:07 Developed in sync with pathologists
03:32 Feedback from users
04:49 More about INIFY®
2020-07-01
Podcast: How is AI revolutionizing digital pathology?

INIFY® Prostate Screening's superpowers to rely on!

Smart
An algorithm is only as smart as its underlying training data. The predicting AI-based engine in INIFY® Prostate Screening is built on deep learning algorithms that are meticulously trained.

Accurate
For real diagnostic confidence, accuracy is everything, and this is where we truly shine.

Robust
INIFY Prostate Screening’s algorithms stand up impressively to known differences between labs, enabling a plug-and-play approach.  
FAST
INIFY® Prostate Screening is designed to help pathologists make the most of their valuable time. 
ADAPTABLE
Our experienced specialists have been working closely together with pathologists from all over the world, creating tools that can be attuned to diverse clinical workflows and user needs. 
RESILIENT
Innovation, technical know-how and professionalism – these are the cornerstones of ContextVision’s enduring market leadership for the last 30 years.

Find out more about how INIFY Prostate Screening empowers the pathologist at www.inify.com

INIFY™ Prostate Screening – powerful, AI-based support software for today’s digital pathology

After years of research and development, working closely together with world-renowned pathologists and a brilliant team of deep learning experts, we are proud to unveil the first product in our INIFY digital pathology portfolio.

INIFY Prostate Screening is a powerful AI-based software that outlines and quantifies suspected cancerous areas in a series of prostate biopsies. It pre-sorts slides in a worst-first order, allowing you to get right to work on the most relevant areas.

The user-friendly viewer, with its prostate-specific design and a wide range of smart tools and handy features, makes it quick and easy for uropathologists to check, confirm and measure suspected cancer and non-cancer structures.

MasterAnnotation™ – for accurate, reliable performance

The INIFY algorithms are trained on data from our MasterAnnotation method – a unique and patented innovation developed by ContextVision. 
MasterAnnotation is our standardized procedure for generating training data. Briefly, a high-resolution multiplex immunofluorescence overlay is used to generate a precise annotation – an augmented ground truth – for the development and optimization of the INIFY algorithms.

In 2019, the MasterAnnotation method was granted patent protection by the U.S. Patent and Trademark Office (USPTO) – ContextVision’s first patent in the digital pathology field; patent US 10,572,996

Seamless integration

Knowing that every clinical environment and pathologist has their own requirements and preferences, we provide a customizable integration as well as an optional, built-in case manager.
The measurement features will improve the accuracy in my reports.
Dr. Michal Ostrowski & Dr. Kinga Sikorski-Mali, ALAB, Warsaw
This tool is so easy to use.
Dr. Margot Dupeux, Hospital Bicetre, Paris
Incredibly fast panning and zooming.
Dr. Witold Rezner, ALAB, Warsaw

INIFY Prostate Screening – designed for clinical pathology

With INIFY Prostate Screening, we wanted to create a tool that truly supports uropathologists’ everyday workflow when handling prostate biopsies. That’s why we developed the INIFY Prostate Screening viewer together with uropathologists. Every detail has been carefully planned and tested to provide a smooth, intuitive user experience that fits your individual needs.

INIFY™ Prostate Screening: Winner of the Frost & Sullivan 2019 European Technology Leadership Award

Each year, this award is presented to a company that has demonstrated uniqueness in developing and leveraging new technologies that deliver significant customer value. Read more here.

The latest breakthroughs in deep learning

The complex patterns in histopathology tissue samples make them challenging to evaluate with classic AI algorithms. However, new machine learning technology has proved to be very powerful for pattern recognition – handling tasks that are highly challenging even for the human brain.

INIFY Prostate Screening is built on deep learning algorithms, which in turn draw on the latest advances in Convolutional Neural Networks (CNNs).
INIFY’s sophisticated algorithms have been developed in collaboration with deep learning experts and pathology specialists. Trained with our patent-filed MasterAnnotation method for auto-annotation of cancer tissue, they provide accurate, reliable and objective outcomes, helping pathologists conclude the diagnosis for each individual patient.

Supporting the pathologist

Today’s pathologists face an ever-increasing number of pathology samples, as well as repetitive, time-consuming and often tedious analysis process. Combined with an all-too-common shortage of qualified pathologists, this risks creating bottlenecks in the treatment process, not to mention stressful working environments.

INIFY powers up the diagnostic workflow, allowing pathologists to realize their full potential as skilled specialists and make the most of their valuable time.

The experience behind our products

Our Digital Pathology team includes many highly experienced specialists from a broad range of fields: experts in immunology and biology, highly skilled project managers, QA/regulatory experts, software engineers, experts on deep learning and AI as well as marketers with a solid business focus. In addition, we have impressive external networks of pathologists, research labs, industry collaborators and other partners. 

The development of our Digital Pathology portfolio builds on the findings of SL-DESUTO, a now finished Eurostars-sponsored research collaboration between ContextVision and the University of Applied Sciences Western Switzerland. ContextVision Advisory Board plays a key role in further strategic research & development within the business unit, providing us with unique and invaluable insights and feedback. The board features some of the most prominent names in the field:

Marilyn M. Bui
MD, PhD 
DPA president 2019, Pathologist, Lab director and Fellowship Program Director at Moffitt cancer Center
Anil Parwani
Professor of Pathology at
The Ohio State University, USA
Dan Ciresan
CEO, Conndera Research,
Romania
Jeroen van der Laak
Associate Professor at Radboud UMC,
Nijmegen, the Netherlands
Junya Fukuoka
MD.PhD. Chair, Professor,
Dept. of Pathology,
Nagasaki University, Japan
Fredrik Pontén
MD, PhD, Dept. of Immunology,
Genetics & Pathology,
Uppsala University, Sweden
Henning Müller
Prof. Dr. 
University of Applied Sciences and
Arts Western Switzerland

I am impressed by the company’s vision and their amazing efforts within AI and machine learning for radiology. I believe that these strengths can help solve some of the current clinical issues that we encounter in pathology today.
Professor Anil Parwani
Ohio State University

Top placements in challenges

Our technological advances have landed us top positions in prestigious competitions using deep learning in digital pathology.
In Tumor Proliferation Assessment Challenge (TUPAC16), we were awarded 2nd place for our breast cancer mitosis detection algorithms and their ability to correctly predict tumor proliferation in whole-slide images. Our results outshone those of many highly reputable academic teams as well as research groups from companies such as IBM and Microsoft.

In CAMELYON17, the goal was to evaluate new and existing algorithms for automated detection and classification of breast cancer metastases in whole-slide images – a task with high clinical relevance, and which normally requires extensive microscopic assessment by pathologists. ContextVision’s algorithms, now further refined and used in INIFY, held a very impressive 2nd place during 2018. 

ContextVision
– a trusted name in diagnostics software

ContextVision is a medical technology software company that specializes in image analysis and artificial intelligence. As the global market leader within image enhancement, ContextVision is a software partner to leading medical imaging manufacturers around the world. Its cutting-edge technology helps doctors accurately interpret medical images, a crucial foundation for better diagnosis and treatment. As an industry pioneer for more than 30 years, ContextVision has developed state-of-the-art capabilities in the latest artificial intelligence technologies. By combining these with its well-established GOP technology, the company is introducing a new generation of image enhancement products. ContextVision is also approaching the growing digital pathology market with new AI-based decision support tools for pathologists.

ContextVision holds an ISO 13485:2016 certification.

The company is based in Sweden, with local representation in the U.S., Russia, Japan, China and Korea. ContextVision is listed on the Oslo Stock Exchange under the ticker COV. 

News and upcoming events

Publications

Filippo Fraggetta

Diagnosing Cancer With Confidence

ThePathologist.com  (11 November  2020)

Read more
Filippo Fraggetta

Clinical‑grade Computational Pathology: Alea Iacta Est

J Pathol Inform 2019, 10:38 (11 December 2019)

Read more
Nikolay Burlutskiy, Nicolas Pinchaud, Feng Gu, Daniel Hägg, Mats Andersson, Lars Björk Kristian Eurén, Cristina Svensson, Lena Kajland Wilén, Martin Hedlund

Segmenting Potentially Cancerous Areas in Prostate Biopsies using Semi-Automatically Annotated Data

International Conference on Medical Imaging with Deep Learning (MIDL2019)
Nikolay Burlutskiy, Feng Gu, Lena Kajland Wilen, Max Backman, Patrick Micke.

A Deep Learning Framework for Automatic Diagnosis in Lung Cancer

International Conference on Medical Imaging with Deep Learning (MIDL2018 in Amsterdam).
Lars Björk, Jonas Gustafsson, Feria Hikmet Noraddin, Kristian Eurén, Cecilia Lindskog.

A new high-throughput auto-annotation method to detect and outline cancer areas in prostate biopsies

Presentation at ECDP 2018 Helsinki, Finland.
Peter Bandi, Oscar Geesink, Ludwig Jacobsson, Martin Hedlund et al.

From detection of individual metastases to classification of lymph node status at the patient level: the CAMELYON17 challenge

IEEE Transaction on Medical Imaging PP(99):1-1, To be released.
Feng Gu, Nikolay Burlutskiy, Mats Andersson, and Lena Kajland Wilén.

Multi-Resolution Networks for Semantic Segmentation in Whole Slide Images

MICCAI 2018 – COMPAY Workshop on computational pathology, Granada, Spain.
Mikael Rousson, Martin Hedlund, Mats Andersson, Ludwig Jacobsson, Gunnar Lathen, Bjorn Norell, Oscar Jimenez-del-Toro, Henning Mueller, Manfredo Atzori.

Tumor proliferation grading from whole slide images

SPIE Medical Imaging, 2018, Houston, Texas, United States.
Sebastian Otalora, Manfredo Atzori, Vincent Andrearczyk, and Henning Muller.

Image Magnification Regression Using DenseNet for Exploiting Histopathology Open Access Content

MICCAI 2018 – COMPAY Workshop on computational pathology, Granada, Spain.
Sebastian Otálora, et. al.

Determining the scale of image patches using a Deep Learning Approach

ISBI 2018. Washington D.C., USA, 2018.
Otálora s., Andrearczyk V., Atzori M., Müller H.

BIWGAN: Learning stable adversarial representations for prostate histopathology images

Medical Imaging Summer School 2018: Medical Imaging meets Deep Learning. Favignana, Italy.
Oscar Jimenez del Toro, Manfredo Atzori, Sebastian Otálora, Mats Andersson, Kristian Eurén, Martin Hedlund, Peter Rönnquist and Henning Müller.

Convolutional neural networks for an automatic classification of prostate tissue slides with high-grade Gleason score

SPIE Medical Imaging, pages 101400O-101400O-9, 2017.
Oscar Jimenez del Toro, Sebastian Otálora, Mats Andersson, Kristian Eurén, Martin Hedlund, Mikael Rousson, Henning Müller and Manfredo Atzori.

Elsevier book on Texture Analysis, chapter Analysis of Histopathology Images

From Traditional Machine Learning to Deep Learning, 2017.
Oscar Jimenez del Toro, Sebastian Otálora, Manfredo Atzori and Henning Müller.

Deep Multimodal Case-Based Retrieval for Large Histopathology Dataset

MICCAI 2017 workshop on Patch-based image analysis, Quebec City, Canada, 2017.
(The paper will be published in Springer LNCS)
DIGITAL PATHOLOGY

Stay tuned

Smart, accurate, fast, adaptable and strong – learn more about how INIFY® Prostate Screening empowers the pathologist. User and developer interviews, short demos and answers to frequently asked questions on both digital pathology and INIFY are examples of upcoming content, sign up here!